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1. Which of the following is (are) true of milrinone lactate (Primacor)?
I. may be administered orally or parenterally
II. produces a positive inotropic action
III. produces vasodilation
A.
B.
C.
D.
E.

2. Which of the products listed below are vaccines?
I. Sandimmune
II. Prograf
III. LYMErix
A.
B.
C.
D.
E.

3. The most serious potential consequence of ingestion of a liquid hydrocarbon such as kerosene or gasoline is
A.
B.
C.
D.
E.

4. The use of clozapine (Clozaril) has been associated with the development of
A.
B.
C.
D.
E.

5. Which of the following is (are) true of pentamidine isethionate (Pentam, NebuPent, Pentacarinat)?
I. may be administered by inhalation
II. may be administered parenterally
III. used to treat RSV infections
A.
B.
C.
D.
E.

6. Which of the following beta-adrenergic blocking agents also exhibit alpha1-adrenergic blocking action?
I. timolol (Blocadren)
II. sotalol (Betapace)
III. labetalol (Normodyne, Trandate)
A.
B.
C.
D.
E.

7. Isotretinoin (Accutane) is a drug employed in the treatment of severe recalcitrant cystic acne. Which one of the following is NOT an adverse effect associated with its use?
A.
B.
C.
D.
E.

8. Which one of the following antibiotics is a third-generation cephalosporin?
A.
B.
C.
D.
E.

9. Cromolyn sodium (Intal, Nasalcrom, Opticrom) is a drug that is
A.
B.
C.
D.
E.

10. Advantages of acetaminophen (Tylenol, APAP) over aspirin include all of the following EXCEPT
A.
B.
C.
D.
E.

11. Which of the following is an active metabolite of primidone (Mysoline)?
I. acetylcholine
II. phenylethylmalonamide
III. phenobarbital
A.
B.
C.
D.
E.

12. Colestipol HCl (Colestid) can best be classified as a (an)
A.
B.
C.
D.
E.

13. Which of the following agents is (are) indicated for the treatment of convulsive disorders
I. clonidine
II. tiagabine
III. topiramate
A.
B.
C.
D.
E.

14. The dose of liothyronine sodium that is approximately equivalent to 100 ).!g of levothyroxine sodium (Synthroid) USP is
A.
B.
C.
D.
E.

15. Which of the following is (are) true of sal-meterol (Serevent)?
I. for the treatment of acute asthma attacks
II. available in an aerosol and inhalation powder form
III. beta 2 agonist
A.
B.
C.
D.
E.

16. Carbon monoxide exerts its toxic effects primarilyby
A.
B.
C.
D.
E.

17. Didanosine (Videx) can best be described as a (an)
A.
B.
C.
D.
E.

18. Which of the following antimicrobial products is (are) prodrugs?
I. cefpodoxime proxetil
II. dirithromycin
III. clindamycin
A.
B.
C.
D.
E.

19. Which one of the following antihistamines would be LEAST likely to cause sedation?
A.
B.
C.
D.
E.

20. Endorphins are
A.
B.
C.
D.
E.

21. Simvastatin (Zocor) acts by
A.
B.
C.
D.
E.

22. Torsemide (Demadex) is most similar in action to
A.
B.
C.
D.
E.

23. In monitoring a patient receiving warfarin for the treatment of acute myocardial infarction, it is important to maintain the INR between
A.
B.
C.
D.
E.

24. Which of the following is (are) true of fentanyl?
I. available as a transdermal system
II. used as a local anesthetic
III. may be used as a cough suppressant
A.
B.
C.
D.
E.

25. Which one of the following is an example of a pure narcotic antagonist?
A.
B.
C.
D.
E.

26. Which of the following bronchodilators act by inhibiting phosphodiesterase?
I. dyphylline (Lufyllin)
II. salmeterol (Serevent)
III. nedocromil sodium (Tilade)
A.
B.
C.
D.
E.

27. The sulfonylureas (eg, Diabinese, Glucotrol) are believed to exert their hypoglycemic effect by
A.
B.
C.
D.
E.

28. Which one of the following drugs is indicated for the treatment of primary nocturnal enuresis?
A.
B.
C.
D.
E.

29. Which one of the following agents is most similar in action to cloxacillin?
A.
B.
C.
D.
E.

30. Of the following glucocorticoids, which one has the greatest anti-inflammatory potency when administered systemically?
A.
B.
C.
D.
E.

31. The "first-dose" effect is characterized by marked hypotension and syncope on taking the first few doses of medication. This effect is seen with the use of
1. doxazosin (Cardura)
II. enalapril (Vasotec)
III. sotalol (Betapace)
A.
B.
C.
D.
E.

32. Stavudine (Zerit) is an antiviral agent employed in the treatment of
A.
B.
C.
D.
E.

33. Liotrix is a thyroid preparation that contains
I. desiccated thyroid
II. levothyroxine sodium
III. liothyronine sodium
A.
B.
C.
D.
E.

34. Which of the following is (are) considered to be prokinetic agents?
I. lansoprazole
II. diphenoxylate
III. metoclopramide
A.
B.
C.
D.
E.

35. Benzodiazepines appear to act as anxiolytics by
A.
B.
C.
D.
E.

36. Most antipsychotic drugs can be said to have which of the following actions?
A.
B.
C.
D.
E.

37. Amrinone (Inocor) is a drug that produces
A.
B.
C.
D.
E.

38. Which of the following is true of pilocarpine (Isopto Carpine, Pilostat)?
I. similar pharmacologic action to dorzolamide (Trusopt)
II. direct-acting mydriatic
III. ingredient in Ocusert ocular therapeutic system
A.
B.
C.
D.
E.

39. Which of the following agents is NOT likely to reduce blood sugar in a patient with type II diabetes mellitus?
I. glucagon
II. pioglitazone
III. repaglinide
A.
B.
C.
D.
E.

40. A common adverse effect associated with the chronic use of magnesium antacids is
A.
B.
C.
D.
E.

41. Morphine can be expected to produce which of the following pharmacological effects?
I. dilation of the pupils
II. respiratory depression
III. constipation
A.
B.
C.
D.
E.

42. The anti-inflammatory effect of NSAIDs is due to their ability to
1. inhibit prostaglandin synthesis
II. inhibit the stimulation of the chemoreceptor trigger zone (CTZ)
III. reset the hypothalamic "setpoint"
A.
B.
C.
D.
E.

43. Which of the following beta-adrenergic blocking agents is beta1-selective?
I. betaxolol (Betoptic)
II. metipranolol HCl (OptiPranolol)
III. timolol (Timoptic)
A.
B.
C.
D.
E.

44. Timentin is a product that contains ticarcillin disodium and clavulanate potassium. Clavulanate potassium
A.
B.
C.
D.
E.

45. Which of the following drugs may interfere with ethanol metabolism?
I. metronidazole (Flagyl)
II. chlorpropamide (Diabinese)
III. disulfiram (Antabuse)
A.
B.
C.
D.
E.

46. Which of the following drugs is (are) sulfonamides?
A.
B.
C.
D.
E.

47. Diflunisal (Dolobid) is most likely to be prescribed for the treatment of
A.
B.
C.
D.
E.

48. Which of the following calcium channel blockers may be employed parenterally in the treatment of cardiac arrhythmias?
I. verapamil (Isoptin, Calan)
II. isradipine (DynaCirc)
III. amlodipine (Norvasc)
A.
B.
C.
D.
E.

49. Which one of the following agents can be administered with ampicillin and other penicillins to achieve higher blood levels of the penicillin?
A.
B.
C.
D.
E.

50. Zidovudine (Retrovir) is indicated for the treatment of patients with
I. hepatitis B infection
II. herpes simplex infections
III. human immunodeficiency virus (HIV) infection
A.
B.
C.
D.
E.

51. Which of the following is (are) true of iso-tretinoin (Accutane)?
A.
B.
C.
D.
E.

52. Which one of the following antimicrobial agents would be MOST useful in the treatment of an infection caused by beta-Iactamase-producing staphylococci?
A.
B.
C.
D.
E.

53. Which one of the following is an effect of atropine on the human body?
A.
B.
C.
D.
E.

54. Amrinone (Inocor) is most similar in action to
A.
B.
C.
D.
E.

55. Acyclovir (Zovirax) is indicated for the treatment of
A.
B.
C.
D.
E.

56. Although classified as antibiotics, dactinomycin (Cosmegen) and plicamycin (Mithracin) are used in cancer chemotherapy because they have a (an)
A.
B.
C.
D.
E.

57. Which of the following agents is (are) classified pharmacologically as carbonic anhydrase inhibitors?
I. fluvastatin
II. nitroprusside
III. acetazolamide
A.
B.
C.
D.
E.

58. Latanoprost (Xalatan) is a drug used in the treatment of glaucoma. Which one of the following best describes its pharmacological action?
A.
B.
C.
D.
E.

59. Which of the following agents is (are) used for the treatment of migraine headaches?
I. rizatriptan benzoate
II. methysergide maleate
III. succinylcholine chloride
A.
B.
C.
D.
E.

60. Which one of the following is NOT a progestin?
A.
B.
C.
D.
E.