Tofacitinib High Yield Notes

How Tofacitinib Works?

Tofacitinib inhibits Janus kinase (JAK) enzymes, JAKs activate signal transducers and activators of transcription (STATs), which regulate gene expression and intracellular activity. Inhibition of JAKs prevents cytokine- or growth factor-mediated gene expression and intracellular activity of immune cells, reduces circulating CD16/56+ natural killer cells, serum IgG, IgM, IgA, and C-reactive protein, and increases B cells.

Adult Dosing

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For hepatic and renal patients, it’s preferred to reduce the dose to once daily, and stop it in case of sever hepatic impairment.